Orajel® Severe P.M. Toothache Pain Relief Cream delivers the highest concentration of pain medicine available without prescription, for instant nighttime relief of your most painful toothaches. The thick cream is long-lasting and easy to apply so you get relief that lasts during the night, when you need it most. Orajel Severe P.M. Toothache Pain Cream goes right to the source of your pain for instant, targeted relief. Don’t trust your toothache pain to anything else.